Press and hold that number to un-block it.

When picking your own numbers, you have the following capabilities:
Lock in numbers you like
If there is a number you really love, you can lock it in and choose the other numbers randomly. To do this, first select the number using the grid, and then hold down on that ball at the top of the screen. A small lock icon will appear on the bottom right corner of the ball. 
Block out numbers you dislike
If there is a number you really hate, you can block that number so that it does not get included in your random picks. To do this, simply hold down on the number in the grid and a big red X will appear on top of the number.
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